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IV and subQ can significantly raise NAD levels in tissues and might yield more pronounced improvements in the short term

(2) normal blood pressure, defined as systolic blood pressure 0.05

An increased liver weight of 110% at one year was not associated with liver tumorigenesis, whereas liver tumorigenicity was seen if the one-year liver weight was 150% of control values (Carmichael et al

However, transcript levels of pro-inflammatory cytokines were not significantly different between vehicle and roxadustat treated mice in both healthy and stroke-affected brain (Figure S4A) suggesting that systemic roxadustat treatment neither promotes inflammation in the intact CNS nor affects the local pro-inflammatory response during acute ischemic stroke

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