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This acidic condition was attributed to the secretion of -lactamase and nitrocefin from E

Loss of HIF1 in Th17 and CD8 T cells, but not other subsets or activation states leads to decreased expression of Glut1 and other key metabolic genes

Nature 372 , 425432 (1994)

This finding implies that the enhanced release of GSH into the extracellular space may play a role in the upregulation of GPX3 activity within the TME