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10.1016/j.phymed.2022.154319 21 JinM

Am J Physiol Heart Circ Physiol 299:H18H24

After treatments with APAP and APAP-CYS in HK-2 cells, we observed that APAP-CYS is even more toxic to kidney cells than APAP itself

Cytokines, particularly pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-), interleukin (IL) -1, IL-6, and IL-17 are central to RA progression by amplifying inflammatory responses and tissue damage (Kugler et al., 2023)