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Discussion The results of the present study could be summarized as follows: 1) levocarnitine supplementation led to an increase in FC, AC and TC levels, irrespective of an improvement of hyperammonemia, 2) levocarnitine add-on therapy was effective in reducing high plasma NH3 concentrations in about half of the subjects with VPA-induced hyperammonemia, 3) baseline levels of AC and longitudinal changes of AC/FC ratios were correlated with fluctuation of NH3 levels from baseline, 4) levocarnitine treatment did not generally exacerbated mental status, but ameliorated a part of psychiatric symptoms

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Gene Expression Level Analysis Total RNA of samples was isolated by using RNAprep Pure Plant kit (Polysaccharides and Polyphenolics-rich) (Tiangen, Beijing, China) and then used to synthesize the first-strand cDNA with FastKing gDNA Dispelling RT SuperMix kit (Tiangen, Beijing, China)

250 Similarly, phytosomal formulations of Triphala and Boswellia serrata have demonstrated improved bioavailability and therapeutic performance in clinical settings

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