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Besides conventional drug discovery approaches, cost-effective ways to accelerate identification of novel antimalarial strategies have included (i) combination therapy, by joining two or more known drugs, (ii) covalent bitherapy, by conjugating different pharmacophores, (iii) repurposing of drugs with other therapeutic indications, and (v) rescuing of known antimalarial scaffolds

A practical framework includes: Use the lowest protocol complexity that answers the question: If one schedule can test the hypothesis, adding extra administrations only adds interpretive burden

We also quantified the levels of 14 and Al 3+ in blue and red cells

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Further, many reported small-molecule inhibitors target several metabolic enzymes with similar structures, for example, EGCG targets both NADPH-dependent FASN and NADP + -dependent GDH