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This detergent theory is mentioned in many reviews to explain colistin-induced nephrotoxicity, yet it is difficult to reconcile with the different biochemistry and physiology of prokaryotic and eukaryotic membranes (Figure 3)

sham-operated group (KruskalWallis test with post hoc test : Chi square = 9.029, df = 3, p = 0.029)]

Animals Male Wistar rats aged 812 weeks and weighing approximately 400 g were obtained from the Chulalongkorn University Laboratory Animal Center (CULAC), Chulalongkorn University