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The optimal retatrutide dose in any research context depends on the balance between efficacy and tolerability

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LPO, lipid peroxide

Korkmaz A, Kaymak SU, Neeliolu S, Erel

Abbreviations AA Arachidonic acid (20:4n-6) ALA Alpha-linolenic acid (18:3n-3) BA 10 Brodmann area 10 CNS Central nervous system cPLA2 A calcium-dependent AA-specific cytosolic PLA2 CSF Cerebrospinal fluid DA Dopamine (3,4-dihydroxyphenethylamine) DHA Docosahexaenoic acid (22:6n-3) DPA Docosapentaenoic acid (22:5n-3) EPA Eicosapentaenoic acid (20:5n-3) FABP Fatty acid binding protein FAD Fatty acid desaturase GM Grey matter GPCR G-protein-coupled receptor GSH Glutathione 5-HT Serotonin (5-hydroxytryptamine) iPLA2 A calcium-independent DHA-specific PLA2 KYNA Kynurenic acid LA Linoleic acid (18:2n-6) NMDAR N-methyl-D-aspartate receptor PANSS Positive and negative symptom scale PFC Prefrontal cortex PLA2 Phospholipase A2 PUFA Polyunsaturated fatty acid PGE2 Prostaglandin E2 RBC Red blood cells RCT Randomized-controlled trial sPLA2 A calcium-dependent AA-specific secretory PLA2 SOD Superoxide dismutase TAC Total antioxidant capacity UHR Ultra-high risk VTA Ventral tegmental area WM White matter Authors contributions The author (MCH, YSH, WCO) contributed to the study conception and design, and writing of the manuscript