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This happens because the blood vessels in affected areas are increasingly fragile, leading to frequent, unexplained bruising

Our analysis of thiamine and its phosphate analogs in stressed plants (Figure 3) showed that the observed changes in the expression of thiamine biosynthetic genes correlated with the activity of the encoded enzymes

The mechanosensing gene PIEZO1 has been linked to joint mobility abnormalities [74], while novel mechanisms involving genes like ULK4 and KCNH1 suggest additional roles in tissue maintenance [74]