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Expanded preclinical evidence of phytochemicals in obesity models Interpretation The results of preclinical researches indicate that the anti-obesity effects of flavonoids, phenolics and saponins are consistently anti-obesity through the mechanisms which include reduction of adipogenesis, increase of fatty-acid oxidation, bettering of insulin sensitivity, and controlling of inflammatory and mitochondrial pathways

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In this regard, oxidants can inhibit multiple protein tyrosine phosphatases including PTP1B and PTEN (Leslie et al., 2003

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doi: 10.1016/j.fertnstert.2021.12.012 2 MinhasSBettocchiCBoeriLCapogrossoPCarvalhoJCilesizNCet al