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Pernicious Anemia Pernicious anemia is an autoimmune condition in which the body attacks the cells that produce intrinsic factor

The IOMs safe upper limit for daily vitamin D intake is 4,000 IU

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High-dose oral therapy (10002000 micrograms daily) can be effective even in pernicious anaemia, as approximately 1% of B12 is absorbed through passive diffusion independent of intrinsic factor

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Individual susceptibility varies considerably, though the factors determining who will be affected remain incompletely understood