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A subset had recurrence of symptoms when rechallenged with the same drug or another bisphosphonate [see Adverse Reactions (6.2)]

Yes, some advanced research protocols combine both

10.3389/fimmu.2013.00480 239 RyanS

A.ZemansR

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Little or no induction of GSNOR was apparent, while among the GPX sequences, GPX5 , GPX6 , and GPX7 were most obviously responsive, although some variation was observed between the experiments, including the two cat2 datasets