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Elias et al reported that the specific overexpression of 5-LOX activating protein (ALOX5AP) in adipose tissue or supplementation with LXA4 results in lower body weight and higher insulin sensitivity than wild-type controls in mice fed an HFD

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This mismatch is further complicated by the fact that standard thyroid panels typically exclude fT3 and rT3 measurements, which can render tissue-level hypothyroidism undetectable through conventional testing

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