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The preclinical models have provided the necessary biological substrate to examine the disease modifying effect of various pharmacological agents and have imperative translational value

This is due to the fact that H 2 O 2 can quickly and readily diffuse through cell membranes, primarily through aquaporins (AQPs) 29,30 , as well as between neighbouring cells through gap junctions hemichannels composed of connexins which facilitate the transfer of molecules 13 kDa large such as ROS between cells to propagate oxidative signals 31

PMID 38896929

doi: 10.1186/s13102-021-00378-x 90 IliakisPStamouEKasiakogiasATsiachrisDFragakisNOikonomouEet al

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