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We recently demonstrated that G6PD deficiency could be induced by either pharmacological inhibitors or G6PD siRNA, which impairs redox homeostasis and causes increased ROS levels and reduced GSH levels in monocytes and endothelial cells

Houstis N, Rosen ED, Lander ES (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance

Moreover, a Zn deficiency upregulates the mammalian ER stress, which indicates the induction of MT synthesis and enhanced stress response [65]

When starting intravenous glutathione treatment, it is necessary to avoid certain factors that may affect its absorption or overall effectiveness

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