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Macrophages, as key effector cells of the innate immune system, play multifaceted and central roles in this process, including immune complex clearance, antigen presentation, inflammation regulation, and tissue repair and fibrosis ( The aberrant activation of the glycolytic pathway serves as a key engine driving the inflammatory response of macrophages in LN

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Clinically, this connection between mycotoxins and mast cell activation may help explain why patients with chronic mold exposure often present with a constellation of symptoms, including brain fog, fatigue, light sensitivity, anxiety, and histamine intolerance, even when traditional testing is unremarkable 13