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Furthermore, studies have shown that optimizing the structure of the gut microbiota, enhancing the abundance of beneficial bacteria such as Muribaculaceae , reducing the number of MMs in colonic tissue, downregulating pro-inflammatory factor expression, and upregulating BMP2 secretion by MMs can enhance gastrointestinal motility, inhibit neuronal loss, and improve slow transit constipation in mice (Ren et al., 2022)