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Research has demonstrated that AGEs can trigger cellular senescence via several mechanisms, including the initiation of p21 in an oxidative stress-dependent manner, upregulation of p16 expression, inhibition of autophagy by diminishing PINK1/Parkin activity, and the promotion of inflammation in renal cells (Liu et al., 2014

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doi: 10.1007/s10517-005-0388-x

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B12 supplements come in various forms, including sublingual tablets, oral tablets, lozenges, and even toothpaste (10)