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Indeed, recent data suggest that a chronic elevation of homocysteine level might indirectly reduce methylation of DNA, RNA, proteins, and phospholipids through a concomitant increase in SAH level secondary to homocysteine-mediated reversal of the SAH hydrolase reaction (Yi et al, 2000)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Ek CJ, Habgood MD, Dennis R, Dziegielewska KM, Mallard C, Wheaton B, et al

If you chose a higher concentration, like 2mg/ml (5ml of bac water), a 250 microgram dose would require you to draw only 0.125ml, which is much more difficult to measure accurately

JAMA Network Open