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Beyond iron handling, NRF2 modulates the GSH antioxidant system by inducing the expression of enzymes required for GSH biosynthesis, such as glutamatecysteine ligase catalytic and modifier subunits (GCLC/GCLM), glutathione synthase (GSS), and the cystine/glutamate antiporter subunit SLC7A11 [114]

Szymaska-Chargot, and A

standard glutathione supplementation is not known to damage healthy kidneys

- Immune Support: Enhances the production and function of white blood cells

Screening for receptor-mediated uptake (e.g., via CD36) should therefore be incorporated into medicinal chemistry workflows

Skin-wise, ALA is an antioxidant that prevents signs of aging and provides protection from environmental damage