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385 PI3K inhibition significantly reduces lactylation levels within tumor cells and reverses the immunosuppressive state of the TME

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Here, we addressed our mechanistic models experimentally using ScGrx7 as a reference enzyme 11,12,18

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.Mao J, et al

Zeineddine FA, Zeineddine MA, Yousef A, Gu Y, Chowdhury S, Dasari A, Huey RW, Johnson B, Kee B, Lee MS, Morelli MP, Morris VK, Overman MJ, Parseghian C, Raghav K, Willis J, Wolff RA, Kawaguchi Y, Vauthey JN, Sun R, Kopetz S , Shen JP