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Functional imaging of legumain in cancer using a new quenched activity-based probe

In general, 2023 was a year of recovery for drug approvals in both markets especially in the US, where approvals seem to have levelled off to a more established pattern in 2024

To verify this, we used RNA-seq and qRT-PCR, which revealed a significant decrease in mitophagy-related gene expression in aged mice compared to young mice (Fig

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IGF-1 DES shows moderately reduced IGFBP affinity, with greater selectivity it particularly reduces affinity for IGFBP-1, IGFBP-2, and IGFBP-4, but retains more binding to IGFBP-3 than IGF-1 LR3 does

Takaoka A, Tanaka N, Mitani Y, Miyazaki T, Fujii H, Sato M, et al