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This review is also very timely given that a recent meeting of CIPN experts at the National Cancer Institute stressed the urgency and importance of developing new theoretical frameworks to understand CIPN ( Limitations of this review Due to heterogeneity in methods such as chemotherapy type, chemotherapy dosing schedule, brain measures, brain interventions, and CIPN assessments (e.g., cold allodynia, mechanical allodynia, mechanical hypersensitivity, and the various tests thereof), the emerging literature in this area reflects only a small number of papers supporting each theme