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In fact, it was demonstrated that Erastin can potentially activate VDAC channel [50], which results in mitochondrial disruption [51] and lead to apoptotic cell death in gastric [52] and colorectal cancer cells [34]

2.3 The relationship between ferroptosis and other programmed cell death responses Ferroptosis is intricately linked to biological processes, including autophagy, endoplasmic reticulum stress, and inflammation, among others, and may be involved in the reciprocal regulation of recalcitrant diseases

The technical sheet explains that glutathione is a powerful antioxidant present inside every cell, involved in the regulation of different cellular events, the repair and synthesis of proteins and DNA, the immune response, the metabolism of toxins and carcinogens, and the prevention of fat oxidation

Therefore, we previously suggested that GSH efflux is necessary to some extent, but not sufficient, for the selective death induction of MRP1-expressing cells 18

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