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doi: 10.3390/ijms21041250 2 BenkhouiliFZMoutawalliAOuchariLEl FahimeEBenzeidHDoukkaliAet al

It is synthesized primarily in the liver, though individual cells can help regulate their own intracellular glutathione levels based on metabolic need

Induction of ferroptosis by erastin, C dot, or FAC and BSO leads to its dissemination to neighboring cells through an iron and lipid peroxide-dependent mechanism, whereas the GPX4 inhibitor ML162 fails to transmit the ferroptosis signal to adjacent cells

Intriguingly, a competitive relationship between the homologues CHAC1 and CHAC2 was observed in human embryonic stem cells (hESCs), where they play opposing roles in maintaining cellular GSH levels and regulating differentiation ( 2.4.2 CHAC1 in neuroprotection and organ injury Similar to its role in stem cell fate, CHAC1/BOTCH exhibits a dual function in regulating neuroprotection and inflammation following neuronal damage and organ injury

Conclusion Our study demonstrated that high GSH levels were significantly associated with a poor prognosis independently of other factors in OC

There was no eligibility restriction on QT/QTc duration