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Conversely, deubiquitinases/DUBs remove ubiquitin chains from substrate proteins, counteracting the activity of E3 ligases, thereby stabilizing the targeted proteins

J.CastleD.et al

Excessive ionophore administration can overwhelm these defenses, leading to systemic copper poisoning, characterized by hepatotoxicity, nephrotoxicity, and hematopoietic suppression [239]