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Since the host-derived damage-associated molecular patterns (DAMPs), like bile acids, can directly engage GSDME to trigger pyroptosis, we reasoned that there might have certain endogenous metabolites capable of inhibiting GSDME activation

6 Multiple microbes in both the small and large intestines can convert dietary L-carnitine into GBB, but relatively few can transform GBB into TMA.13 The GBB-to-TMA conversion is much higher in omnivores than in vegans and vegetarians, likely because of differences in the gut microbiota, although this aspect of the L-carnitine-to-TMAO pathway is not fully understood

doi: 10.1038/labinvest.2016.135 114 ZhangFXiaoYHuangZWangYWanWZouHet al

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Those who are trying to get pregnant should avoid diclofenac, as it can delay ovulation and reversibly impact fertility