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In the expression of genome-encoded proteins, integration of genome offers lower copy number of gene

While this finding was discussed in the context of peripheral clock function, we speculate that it may also suggest that the central pacemakers role is less dominant than traditionally assumed, and that peripheral clocks can, under certain conditions, exert substantial autonomous control over specific physiological functions or even over organismal homeostasis

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Giagulli, C

Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment

There were a few limitations in this study such as using only male rodents to prevent a possible compounding effect of female hormones