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The compound's LogP value, a measure of lipophilicity, has been reported in the range of 3.2-3.8, indicating significant hydrophobic character

NND was positive in only one test system, i.e., HepG2 cells with hamster S9-mix, already at the lowest tested concentration (5 M)

Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: post hoc analysis of a randomized controlled 4.3 year trial

Failure of these treatment modalities, worsening condition or symptoms, continued loss of Meibomian glands as seen on meibography, or recurrent infections of eyelids, is highly suggestive of OMGD, a severely underdiagnosed condition

Gradual titration from the lowest dose is always the safest approach when introducing a new compound with a different mechanism of action

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