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Interestingly, 8.7% of DEGs in the entire data set coded for mitochondrial proteins, which were generally downregulated (Supplementary Data 1)

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Subsequent clinical double-blind controlled trials indicated that multi-dose flavonoid regimens (200800 mg daily) were safe, well-tolerated, and without significant accumulation, supporting the potential of flavonoid-based supplements in PD management (Pang et al., 2016)