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Arabidopsis mutant phenotypes for cadmium tolerance ( cad2 ), plant disease resistance ( pad2 ), and post-embryonic root development ( rml1 ) are linked to the GCL gene (Cobbett et al., 1998

doi: 10.1038/ejcn.2012.135 306

e-Pub 1977

This structural insight has been instrumental in the design of inhibitors targeting specific GST subtypes as the G-site recognizes only GSH as a substrate, making it a prototype for developing G-site inhibitors