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Utilizing electrostatic interactions, positively charged COFs were successfully loaded with Poly(I:C), followed by coating MnO 2 on the surface via an in-situ growth strategy, ultimately yielding MnO 2 -Poly(I:C)@COF composites ( Figure 4D )

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Acknowledgments We thank the Corporacin Ecuatoriana para la Investigacin y la Academia (CEDIA) and its funds from CEPRA XII-2018-10 granted to LG

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