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On the other hand, epigenetic dysfunction modifies metabolism by directly affecting the expression of metabolic enzymes (3) and altering the signal transduction cascades involved in the control of cell metabolism (4) (Figure 3)

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These factors include haem oxygenase-1, which has important anti-inflammatory properties toward cytokines including upregulating IL-10, and downregulating IL-6 and TNF through other means, such as NF-B signalling