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The H-site composed of mainly hydrophobic residues is responsible for the substrate binding [75]

However, researchers estimate that the lethal dose of GHK-Cu would be about 330 mg/kg of body weight, which is over 300 times larger than its known effective dose

doi: 10.1111/j.1469-7580.2007.00733.x 218 McdonaldJ

In this Perspective, we cover the range of injury to OLs and intrinsic versus extrinsic influences on OLs, and reflect on how this knowledge may be harnessed for therapeutic development