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Mitochondrial dysfunction in down syndrome: Molecular mechanisms and therapeutic targets

Panday et al., 2015)

Removing pyruvate in the media prevents the recycling of NADH into NAD + by the cytosolic LDH enzyme, forcing mitochondrial redox shuttle systems to support cytosolic redox balance 18

TereshkoYDal BelloSDi LorenzoCPezSPittinoASartorRet al

N., Ciriolo, M

The pharmacologic inhibition of the xc antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis