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10.1038/s41598-020-75009-5 Sci

doi: 10.1016/j.expneurol.2024.115084, 124 WilliamsonT

Neh4 and Neh5 are acidic conserved sequences that enhance the expression of Nrf2 target genes by binding cAMP responsive element binding protein ( As mentioned above, Nrf2 ubiquitinated by the Keap1-CUL3 complex under normal conditions is degraded by proteases in the cytoplasm

They did it using a molecule called SNAC a permeation enhancer that took decades to develop, required a $1.8 billion acquisition of the company that created it, and involved over 9,500 patients across ten Phase 3 trials

Such injury is associated with amoxicillinclavulanic acid, anabolic steroids, chlorpromazine, erythromycins, estrogens, phenothiazines or tricyclics [1,8]

Mourelle M