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Men have a lower survival rate than women, which may be explained by immunomodulation by sex hormones, age and X-linked gene expression and provide an insight on course of infection and sex differences (Haitao et al

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In line with this idea is a genetic study identifying a missense mutation, A240E located in the second extracellular loop, resulting in reduced constitutive activity and leading to familial short stature (Pantel et al., 2006)

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