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Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial

Indeed, ragweed pollen extract depleted cellular GSH and induced lipid peroxidation, which directly induced tyrosine phosphorylation of p38 MAPK and subsequent production of interleukin IL-8

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In previous years, ferroptosis has been shown to serve a key role in numerous pathological processes, including neurodegenerative diseases, cancer and inflammation-related disorders (3)

When abundantly incorporated into membrane phospholipids, PUFAs greatly increase cellular susceptibility to ferroptosis due to their high autoxidation potential ( 3.1.2 Expression and regulation of key enzymes Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are key enzymes that modulate phospholipid synthesis and remodeling

Ibrahim, R