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The induction of apoptosis was mainly studies on CD38 + MM cells and was verified by studying the morphological changes, phosphatidylserine translocation, loss of mitochondrial membrane potential and loss of membrane integrity after treatment [70]

Zhao L (2019) Protective effects of trimetazidine and coenzyme Q10 on cisplatin-induced cardiotoxicity by alleviating oxidative stress and mitochondrial dysfunction

More importantly, the downregulation of the EZH2 gene leads to a decrease in LAT1 ( SLC7A5 ) expression, and, in turn, the downregulation of LAT1 ( SLC7A5 ) or the depletion of essential amino acids can also induce a decrease in EZH2 expression (Dann et al., SLC7A5 ) indicates the potential of LAT1 ( SLC7A5 ) as a target for cancer therapy (Hafliger and Charles, 2019)

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In addition, the electrophoretic mobility of GSAAT(WT) and the GSAAT(CS) lines is altered by the thiol-reactive compound AMS

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