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We screened candidate mutant lines by PCR and Sanger sequencing and identified the Atg8a 12 allele that carries an 8-bp deletion based on sequencing data (Fig S2A), which causes frameshift in all isoforms of the Atg8a gene

Among the contractile prostaglandins of airway smooth muscle, PGD 2 and PGF 2 stand out

however, while senolytics focus on the selective elimination of senescent cells, senomorphics aim to rejuvenate their functionality without necessarily inducing cell death