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Longer regimens remain viable for patients with additional resistance, intolerance to short-course drugs, severe disease, pregnancy, certain extrapulmonary TB cases, or other complex needs, with alternative agents recommended as needed (i.e., streptomycin, levofloxacin, clofazimine, and delamanid) (Vanino et al., 2023)

50 In addition to the bacterial genomic mutations, plasmid-mediated mechanisms play an important role in the generation of quinolone resistance

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The Kihito formula, when combined with ChEIs therapy, significantly improved cognitive scores in Mini-Mental-State Examination Japanese (MMSE-J) evaluations, surpassing monotherapy outcomes (Watari et al., 2019)