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Downregulation of ADORA2A was associated with increased levels of 5mC and decreased levels of 5hmC in the 5 untranslated region (UTR) region of ADORA2A in the putamen of HD patients

J Mol Cell Biol 11(4):330341 Fatima I, El-Ayachi I, Playa HC et al (2019) Simultaneous multi-organ metastases from chemo-resistant triple-negative breast cancer are prevented by interfering with WNT-signaling

8.4.4 Translation of preclinical evidence to clinical practice: critical methodological gaps A systematic evaluation of the evidence base presented in this review reveals significant translational barriers between preclinical mechanistic studies and clinical efficacy validation

A 2020 review found a small study indicating that inhaled boiled black seed extract has a potential bronchodilatory effect on people with asthma, improving all markers of lung function and respiratory rate (i.e., helping them breathe better)