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In the blood stream and organ tissues, circulation and accumulation of MDA is one of the major contributions to induce oxidative stress resulting in cancer, diabetes, asthma, atherosclerosis and Alzheimers disease (Dalle-Donne et al

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doi: 10.1152/physiol.00041.201 81 GoodeHFRobertsonDAKelleherJWalkerBE

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2008;131(6):i5

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Cross-linking in collagen and elastin

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Trends are largest in the Indian sector ( km 2 per decade

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1.5.2.3 Extracellular matrix remodeling and barrier breakdown Matrix metalloproteinases (e.g., MMP-2, -9, -13) contribute to structural degradation of the epithelial barrier and may represent a critical transition point from reversible injury to sustained pathology

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