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Endothelial cells may mediate early inflammatory responses through expression of proinflammatory factors, like IL-1 (Iannucci et al., 2022), that activate microglia

Although the anti-inflammatory effects of the CB 2 R are well-characterized, it is also important to note that the CB 2 R seems essential for many environmental-induced immune responses in microglia

Where indicated, HFF-1-containing media were also incubated with a different treatment of either 10 or 30 mM GSH, or 4 g/mL amikacin alone, or a combination of 10 mM GSH + 4 g/mL amikacin, either in the presence or absence of bacteria

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Graphical Abstract A bidirectional relationship between sleep and oxidative stress has been shown, indicating that sleep may play a protective role against the accumulation of reactive species during wakefulness and sleep deprivation