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There are several publications suggesting that G-proteins might work in conjunction with RTKs

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2) enhancement of Mdm2 binding through productive interactions via the C-terminal tail, 3) tail stability through sequence optimization, residue a-methylation (addition of a methyl group to the amino acids alpha-carbon, a modification that is known to inhibit protease cleavage 27 ), and/or additional staples

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As a precaution, the drugs are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2 syndrome