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a number of the agonists in Table 1 (Families 2-5) have norleucine at R 1 , or an amino acid residue a number of an amino acid residues may be used at residue R 1 , including without limitation, tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, norvaline, ornithine, S-benzyl cysteine amino acid residues

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Mice were euthanized in a non-fasted state over 2 days during their sleep cycle