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doi: 10.1016/j.aninu.2017.06.007 47

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When DAMPs, such as HMGB1 and ATP, bind to pattern recognition receptors (PRRs) on the surface of DCs (e.g., TLR and NLRP3), they trigger DC maturation, enhance antigen processing and presentation capabilities (86), and promote the secretion of proinflammatory factors such as IL-12 and TNF-, as well as CCR7-mediated lymph node homing