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Also, it opposes the nowadays aggressive wound management if it considers in fistulas healing mostly local skin protection (Orangio, 2010

5, 6 DR targets whole-body metabolism, impacting hormones, metabolic substrates and molecular signaling pathways that have a role in metabolic disorders such as obesity and T2D

This in turn induces the expression of antioxidant and detoxifying genes, providing a defensive response against OS [167,168]

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Oxidative stress can also drive the progression of diabetic liver toward inflammation and fibrosis by activating pro-inflammatory signaling pathways (42)