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[DOI] [PubMed] [Google Scholar] 84.Gao X., Yue C., Tian R., Yu L., Tian F., Zhao J., Chen W., Zhai Q

Vermeersch & Styczynski, 2013)

Toll-like receptors and the control of immunity

Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

This metabolic transformation also results in reduced affinity of the compound for its cellular target

Our separate assessment of each metabolite using optimized enzymatic assays was calibrated against validated standards and LC-MS and allows high-throughput analyses