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The PD-1/PD-L1 pathway plays a crucial role in immune tolerance by fine-tuning the quality and duration of T cell response thereby serving as a rheostat of immune response (262, 263)

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Additionally, disruption of the bloodbrain barrier (BBB) occurs through endothelial injury, tight junction breakdown, and matrix metalloproteinase activation, which increases vascular permeability and contributes to cerebral edema and secondary injury (28)

These investigations suggest that selenium has a 2-fold effect on mycotoxin-induced autophagy

GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine

These findings support the hypothesis that glycocalyx disruption contributes to the pathophysiology of DCI through mechanisms such as neuro-inflammation, microthrombosis, endothelial dysfunction, and oxidative stress (66)