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5.2 Cellular crosstalk Intestinal epithelial cells (IECs) constitute a critical physical barrier that segregates the intestinal lumen, with its diverse contents, including digested nutrients, commensal microbiota, and potential pathogens, from the underlying mucosal immune system (164)

C., Ibi, A., Wood, S., Hardy, M., Gahler, R

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6.1.2 Gut-derived factors Intestinal I/R injury leads to the leakage of gut-derived factors such as bacterial endotoxins (lipopolysaccharide, LPS), metabolites, and cytokines into the bloodstream (Nie et al., 2024)

However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71

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